We collected demographic data and atherosclerotic risk factors from all patients within 24 h of admission. All patients were started on dual antiplatelet treatment with aspirin (150–300 mg/day) and clopidogrel (75 mg/day, first 300 mg) within 24 h after admission, and they adhered well to regular medication during the follow-up period. Outpatient follow-up was performed 3, 6, 9, and 12 months after discharge. Stroke recurrence was defined as the presence of a new acute infarct focus in the same vascular supply area on diffusion-weighted imaging (DWI) (n = 30). When no imaging was available for the suspected recurrent event, the follow-up was based on the characteristics of the new neurological deficit symptoms (National Institute of Health stroke scale (NIHSS) increase > 4 points) and duration (>24 h) to determine the occurrence of the outcome event (n = 11) [11 (link)]. The follow-up time was defined as during the time of diagnosis to the endpoint events or to the most recent follow-up if no event occurred. The “last observation carried for-ward” protocol was followed for incomplete follow-up data.
Retrospective Analysis of Symptomatic Intracranial Atherosclerosis
We collected demographic data and atherosclerotic risk factors from all patients within 24 h of admission. All patients were started on dual antiplatelet treatment with aspirin (150–300 mg/day) and clopidogrel (75 mg/day, first 300 mg) within 24 h after admission, and they adhered well to regular medication during the follow-up period. Outpatient follow-up was performed 3, 6, 9, and 12 months after discharge. Stroke recurrence was defined as the presence of a new acute infarct focus in the same vascular supply area on diffusion-weighted imaging (DWI) (n = 30). When no imaging was available for the suspected recurrent event, the follow-up was based on the characteristics of the new neurological deficit symptoms (National Institute of Health stroke scale (NIHSS) increase > 4 points) and duration (>24 h) to determine the occurrence of the outcome event (n = 11) [11 (link)]. The follow-up time was defined as during the time of diagnosis to the endpoint events or to the most recent follow-up if no event occurred. The “last observation carried for-ward” protocol was followed for incomplete follow-up data.
Corresponding Organization : Yangzhou University
Variable analysis
- Presence of suspected intracranial atherosclerotic stenosis (sICAS)
- Stroke recurrence
- Presence of a new acute infarct focus in the same vascular supply area on diffusion-weighted imaging (DWI)
- Characteristics of new neurological deficit symptoms (National Institute of Health stroke scale (NIHSS) increase > 4 points) and duration (>24 h)
- Complete baseline demographic data and atherosclerotic risk factors data
- HR-VWI examination performed within one week of onset
- All culprit vessels had plaque formation
- No non-atherosclerotic vascular disease (such as vascular malformation or intracranial aneurysm)
- No endovascular therapy received
- No ipsilateral extracranial artery stenosis ≥ 50%
- No combined potential cardiogenic embolic factors (e.g., atrial fibrillation)
- No poor image quality
Annotations
Based on most similar protocols
As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!