PET and MRI Imaging Protocols in Neurodegenerative Studies

We acquired PET images using the following PET/computed tomography (CT) scanners: Biograph mCT (Siemens) in Seoul,^{32 (link)} Discovery 690 (GE Healthcare) in BioFINDER-1, Discovery MI (GE Healthcare) in BioFINDER-2,^{13 (link),17 (link)} Biograph 6 Truepoint (Siemens) at UCSF and BACS,^{12 (link),33 (link)} and multiple scanners in the multicenter ADNI^{34 (link)} and Avid Radiopharmaceuticals^{23 (link)} cohorts. All PET data were reconstructed at the respective sites into 4 × 5-minute frames within the 80- to 100-minute ([¹⁸F]flortaucipir) and 70- to 90-minute ([¹⁸F]RO948) intervals after injection. Amyloid PET was performed using carbon 11 (¹¹C)–Pittsburgh Compound B (BACS and UCSF), [¹⁸F]florbetapir (Avid Radiopharmaceuticals and ADNI subsets), [¹⁸F]florbetaben (Seoul and ADNI subsets), or [¹⁸F]flutemetamol (BioFINDER-1 and BioFINDER-2). Magnetic resonance images were acquired on the following scanners: 3.0-T Discovery MR750 (GE Healthcare) in Seoul,^{32 (link)} 3.0-T Tim Trio (Siemens) or 3.0-T Prisma (Siemens) in BioFINDER-1 and -2,^{13 (link),17 (link)} 3.0-T Tim Trio or 3.0-T Prisma (Siemens) at UCSF,^{33 (link)} 1.5-T Magnetom Avanto (Siemens) for BACS,^{12 (link)} and multiple 1.5-T and 3-T scanners in the multicenter ADNI^{34 (link)} and Avid Radiopharmaceuticals^{23 (link)} cohorts.

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Ossenkoppele R., Smith R., Mattsson-Carlgren N., Groot C., Leuzy A., Strandberg O., Palmqvist S., Olsson T., Jögi J., Stormrud E., Cho H., Ryu Y.H., Choi J.Y., Boxer A.L., Gorno-Tempini M.L., Miller B.L., Soleimani-Meigooni D., Iaccarino L., La Joie R., Baker S., Borroni E., Klein G., Pontecorvo M.J., Devous MD S.r., Jagust W.J., Lyoo C.H., Rabinovici G.D, & Hansson O. (2021). Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging. JAMA Neurology, 78(8), 961-971.

Publication 2021

Biograph mCT Discovery 690 Discovery MI Biograph 6 Truepoint 3.0-T Discovery MR750 3.0-T Tim Trio 3.0-T Prisma 1.5-T Magnetom Avanto

Amyloid Carbon 11 Computed tomography scanners Florbetaben Florbetapir Flortaucipir Flutemetamol Frames Pittsburgh compound b Prisma Radiopharmaceuticals Trio

Corresponding Organization : Skåne University Hospital

Other organizations : Gangnam Severance Hospital, Yonsei University, Korea Institute of Radiological and Medical Sciences, University of California, San Francisco, University Memory and Aging Center, Lawrence Berkeley National Laboratory, Roche (Switzerland), University of California, Berkeley

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Variable analysis

independent variables

Type of PET/CT scanner used (Biograph mCT, Discovery 690, Discovery MI, Biograph 6 Truepoint)
Tracer used for amyloid PET (11C-Pittsburgh Compound B, 18F-florbetapir, 18F-florbetaben, 18F-flutemetamol)
Type of MRI scanner used (3.0-T Discovery MR750, 3.0-T Tim Trio, 3.0-T Prisma, 1.5-T Magnetom Avanto)

dependent variables

PET data reconstructed into 4 × 5-minute frames within the 80- to 100-minute (18F-flortaucipir) and 70- to 90-minute (18F-RO948) intervals after injection

control variables

Injection interval for PET tracers (80- to 100-minute for 18F-flortaucipir, 70- to 90-minute for 18F-RO948)

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