Quantification of Ginseng Extracts and Metabolites

RGE—an extract from dried root of ginseng of 6 years and more than 60% of dried ginseng content, 13.2 mg marker ginsenosides (GRb1 + GRg1 + GRg3), and 34.7 mg total ginsenosides per gram extract—was purchased from the Punggi Ginseng Cooperative Association (Youngjoo, Kyungpook, Korea) [29 (link),30 (link),31 (link),32 (link)]. Amlodipine besylate, hydrochlorothiazide, and berberine hydrochloride (IS) were purchased from Sigma-Aldrich Chemical Co. (St. Louis, MO, USA). Fimasartan potassium trihydrate (fimasartan) and the oxidized desulfurized metabolite of fimasartan (fimasartan-amide) were obtained from Boryung Pharm. Co. Ltd. (Seoul, Korea). All other chemicals and solvents were of reagent or analytical grade.

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Jeon S.Y., Jeon J.H., Park J.H., Lee J., Pang M., Choi M.K, & Song I.S. (2022). Simultaneous Analysis of a Combination of Anti-Hypertensive Drugs, Fimasartan, Amlodipine, and Hydrochlorothiazide, in Rats Using LC-MS/MS and Subsequent Application to Pharmacokinetic Drug Interaction with Red Ginseng Extract. Toxics, 10(10), 576.

Publication 2022

Amlodipine besylate hydrochlorothiazide berberine hydrochloride

Amide Amlodipine besylate Berberine Fimasartan Ginseng Ginsenosides Hydrochlorothiazide Potassium Root Solvents

Corresponding Organization : Kyungpook National University

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Variable analysis

independent variables

Dried root of ginseng of 6 years and more than 60% of dried ginseng content
Marker ginsenosides (GRb1 + GRg1 + GRg3) content (13.2 mg/g extract)
Total ginsenosides content (34.7 mg/g extract)

dependent variables

Not explicitly mentioned

control variables

Amlodipine besylate
Hydrochlorothiazide
Berberine hydrochloride (IS)
Fimasartan potassium trihydrate (fimasartan)
Oxidized desulfurized metabolite of fimasartan (fimasartan-amide)

positive controls

Amlodipine besylate
Hydrochlorothiazide
Fimasartan potassium trihydrate (fimasartan)
Oxidized desulfurized metabolite of fimasartan (fimasartan-amide)

negative control

Berberine hydrochloride (IS)

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