ATAC-seq was performed as previously described (47 (link)). The amplicon libraries for sequencing were quantified using a LabChip GX Touch (PerkinElmer) and KAPA Library Quantification Kit (KAPA Biosystems, #KK4824) and sequenced with 150-cycle MiSeq Reagent Kits v3 (Illumina) using paired-end sequencing (2 × 75 cycles) on an Illumina MiSeq, according to the manufacturer’s recommendations.