Blood and urine samples were collected from each subject after INS diagnosis and before steroid treatment. A total of 87 variables were collected (Supplementary Table 1). Demographic characteristics were collected, including age, sex, and weight. By hematological tests, 43 variables were analyzed, including white blood cell counts, percentage of neutrophils, percentage of lymphocytes, hemoglobin, platelet, C-reactive protein, ESR, total protein, albumin, globulin, alanine aminotransferase, aspartate aminotransferase, serum creatinine, urea, serum cystatin c, serum β2-MG, triglyceride, cholesterol, antistreptococcal hemolysin O, prolonged prothrombin time, fibrinogen, prolonged activated partial thromboplastin time, prolonged thrombin time, D-dimer, IgG, IgA, IgM, C3, C4, retinol conjugated protein, total IgE, IL-2, IL-4, IL-6, IL-10, TNF, IFN-γ, CD19%, CD3%, CD4%, CD8%, CD3-CD16+CD56+%, and CD4/CD8. By urine tests, 25 variables were analyzed, including urine occult blood, urine protein, urine specific gravity, urinary RBC, urinary WBC, urinary microprotein, 24-hour urine protein, urinary microalbumin, urinary α1-MG, urinary β2-MG, urinary transferrin, urinary retinol conjugated protein, urinary IgG, uric acid, 24-hour uric acid, urinary protein/creatinine, urinary calcium, 24-hour urinary calcium, urinary calcium/creatinine, urinary microalbumin/creatinine, urinary α1-MG/creatinine, urinary β2-MG/creatinine, urinary transferrin/creatinine, urinary retinol conjugated protein/creatinine, and urinary IgG/creatinine. A total of 17 autoantibodies to podocyte proteins were detected, including talin-1 (Tln1), moesin (Msn), myosin light chain 1 (Myh1), vinculin (Vcl), aconitate hydratase, mitochondrial (Aco2), cytoskeleton-associated protein 4 (Ckap4), desmoglein 1 (Dsg1), proteasome subunit alpha type-1 (Psma1), F-actin-capping protein subunit beta (Capzb), filamin-A (Flna), plectin (Plec), heat shock protein HSP 90-beta (Hs90a), peptidyl-prolyl cis-trans isomerase D (Ppid), peroxiredoxin-1 (Prdx1), alpha-enolase (Eno1), neuroblast differentiation-associated protein AHNAK (Ahnak), and serine/arginine-rich splicing factor 9 (Sfrs).
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