The study was approved by an appropriately constituted ethic committee of the National Taiwan University Hospital (Institutional Review Board Number: 201507061RINB), and the written informed consents were obtained from all participants. This study was a retrospective cohort analysis involving women with an indication for COS in IVF or oocyte donation programs between January 2013 and September 2014. All patients were recruited from the Outpatient Department of the Stork Fertility Center (Hsinchu, Taiwan), and were counseled by fertility specialists regarding the stimulation protocol design before treatment began. A single dose of corifollitropin alfa followed by short-acting gonadotropin supplements was administered. Serum hormone levels (luteinizing hormone [LH], oestrodial [E2], progesterone [P4]) and stimulated follicle size were monitored during the follicular phase. Flexible GnRH antagonist administration based on the monitoring serum LH levels was used in the patients. Every patient was treated with corifollitropin alfa in only one IVF cycle. Patients with multiple IVF cycles were not included in this study. The harvested blastocysts were cryopreserved. All of the patients went through frozen-thawed blastocyst transfer(s) in the other menstrual cycle(s) to decrease the OHSS risk and to increase the success rate by optimizing the endometrial synchronization [14 ].
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