The efficacy population included all 444 patients who were assigned to a cohort. The safety population included all 449 patients who received 1 or more doses of ponatinib. The planned sample sizes for the cohorts were estimated to rule out prespecified null response rates with the use of 95% confidence intervals as specified in Appendix B in the Supplementary Appendix. Two-sided, exact 95% confidence intervals were calculated for rates of a major cytogenetic response, major hematologic response, complete hematologic response, and major molecular response. The duration of response, progression-free survival, and overall survival were estimated with the use of the Kaplan–Meier method. Fisher’s exact test was used for subgroup comparisons.