A proteomic profiling platform has been developed that applies 5,034 single-stranded DNA aptamers (validated SOMAmers™) to assay 4,783 human proteins (4,137 distinct human gene targets), 48 non-human vertebrate proteins and 203 bacterial and viral protein targets covering a broad range of protein functional classifications (Supplemental Figure 1 ). The intra-assay and inter-assay CVs are presented in the Results section. As compared to the prior iteration of the platform, this version covers a broader array of intracellular proteins (approximately 30%).
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Comprehensive Proteomic Profiling Platform
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A protein
Assay
Bacterial
Dna aptamers
Human proteins
Intracellular
Protein targets
Proteins array
Vertebrate
Corresponding Organization :
Other organizations : Cardiovascular Research Center, Novartis (United States), Brigham and Women's Hospital, Beth Israel Deaconess Medical Center
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Variable analysis
independent variables
- Development of a proteomic profiling platform
- Assay of 4,783 human proteins (4,137 distinct human gene targets)
- Assay of 48 non-human vertebrate proteins
- Assay of 203 bacterial and viral protein targets
- Intra-assay and inter-assay CVs
- Broad range of protein functional classifications
- No positive or negative controls were explicitly mentioned in the input.
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