PET Imaging of Amyloid-β Deposition

The dynamic ¹¹C-labeled Pittsburgh compound B tracer PET scans were performed on an Advance PET scanner (GE Healthcare, Milwaukee, Wis), and distribution volume ratio images were calculated in the native space of each PET image (26 (link),27 (link)). Mean distribution volume ratio in each selected ROI was quantified and a global index of cortical distribution volume ratio value greater than a threshold of 1.06 was considered positive for Pittsburgh compound B (or positive for amyloid-β; Appendix E7 [online]).

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Chen L., Soldan A., Oishi K., Faria A., Zhu Y., Albert M., van Zijl P.C, & Li X. (2020). Quantitative Susceptibility Mapping of Brain Iron and β-Amyloid in MRI and PET Relating to Cognitive Performance in Cognitively Normal Older Adults. Radiology, 298(2), 353-362.

Publication 2020

Advance PET scanner

Amyloid Cortical Pet scans Pittsburgh compound b

Corresponding Organization :

Other organizations : Johns Hopkins University, Johns Hopkins Medicine, Kennedy Krieger Institute

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Variable analysis

independent variables

Dynamic ¹¹C-labeled Pittsburgh compound B tracer PET scans

dependent variables

Mean distribution volume ratio in each selected ROI
Global index of cortical distribution volume ratio value greater than a threshold of 1.06 (considered positive for Pittsburgh compound B or positive for amyloid-β)

control variables

PET scans performed on an Advance PET scanner (GE Healthcare, Milwaukee, Wis)
Distribution volume ratio images calculated in the native space of each PET image

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