MRI Biomarkers for Neurodegenerative Diseases

The acquisition of MRI scans has been extensively described previously [24 (link)]. During the period of 2005 to 2017, the following scanners have been used: Discovery MR750 and Signa HDXT (both GE Medical Systems, USA), Ingenuity TF PET/MR (Philips Medical Systems, The Netherlands), Titan (Toshiba Medical Systems, Japan), and Magnetom Impact and Sonata (Siemens Healthcare, Germany). The MRI protocol included 3D T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR), gradient-echo T2*, and/or susceptibility-weighted imaging sequences. The scans were visually assessed by a neuroradiologist on three different image planes. Parietal atrophy was rated using the posterior cortical atrophy (PCA) scale [46 (link)], medial temporal atrophy using the medial temporal lobe atrophy (MTA) scale [47 (link)], and the extent of white matter hyperintensities according to the Fazekas scale [48 (link)]. MTA and PCA scores were scored separately for right and left and averaged thereafter. In addition, the scans were assessed for the existence of lacunes and microbleeds.

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Reimand J., de Wilde A., Teunissen C.E., Zwan M., Windhorst A.D., Boellaard R., Barkhof F., van der Flier W.M., Scheltens P., van Berckel B.N., Ossenkoppele R, & Bouwman F. (2019). PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases. Alzheimer's Research & Therapy, 11, 100.

Publication 2019

Discovery MR750 Signa HDXT Ingenuity TF PET/MR Titan

Atrophy Cortical Echo Inversion Mri scans Scans Sonata Susceptibility Temporal lobe White matter

Corresponding Organization : Vrije Universiteit Amsterdam

Other organizations : Lund University

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Variable analysis

independent variables

Scanners used: Discovery MR750 and Signa HDXT (both GE Medical Systems, USA), Ingenuity TF PET/MR (Philips Medical Systems, The Netherlands), Titan (Toshiba Medical Systems, Japan), and Magnetom Impact and Sonata (Siemens Healthcare, Germany)

dependent variables

Parietal atrophy rated using the posterior cortical atrophy (PCA) scale
Medial temporal atrophy using the medial temporal lobe atrophy (MTA) scale
Extent of white matter hyperintensities according to the Fazekas scale
Existence of lacunes and microbleeds

control variables

The scans were visually assessed by a neuroradiologist on three different image planes

Annotations

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