AdipoRon Treatment Enhances Cognitive Function

AdipoRon (Sigma-Aldrich, MO, USA) was first dissolved in DMSO at 40 mg/mL, then suspended in 0.5% carboxymethylcellulose salt (Sigma-Aldrich, St. Louis, MO, USA) [35 (link),78 (link)]. Animals received the AdipoRon treatment (20 or 50 mg/kg i.p.) or the vehicle as control treatment continuously for 14 days. Mice were injected with bromodeoxyuridine i.p. (BrdU: 50 mg/kg dissolved in 0.9% saline) before AdipoRon treatment to study newborn cell survival. The day after the last treatment, mice were subjected to an open field test and Y-maze task, as illustrated in Figure 7.

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Lee T.H., Christie B.R., van Praag H., Lin K., Siu P.M., Xu A., So K.F, & Yau S.Y. (2021). AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis. International Journal of Molecular Sciences, 22(4), 2068.

Publication 2021

AdipoRon

0 9 saline Adiporon Animals Brdu Bromodeoxyuridine Carboxymethylcellulose Cell survival Dmso Maze Mice Newborn Open field test Salt

Corresponding Organization : Hong Kong Polytechnic University

Other organizations : University of Victoria, Florida Atlantic University, Guangdong 999 Brain Hospital, Guangzhou Psychiatric Hospital, Guangzhou Medical University, University of Hong Kong, Jinan University

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Variable analysis

independent variables

AdipoRon treatment (20 or 50 mg/kg i.p.)
Vehicle as control treatment

dependent variables

Newborn cell survival
Performance in open field test
Performance in Y-maze task

control variables

AdipoRon first dissolved in DMSO at 40 mg/mL, then suspended in 0.5% carboxymethylcellulose salt
Mice injected with bromodeoxyuridine i.p. (BrdU: 50 mg/kg dissolved in 0.9% saline) before AdipoRon treatment
AdipoRon or vehicle treatment administered continuously for 14 days

controls

Positive control: Vehicle as control treatment
Negative control: Not explicitly mentioned

Annotations

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