Immediately before and after infection, we quantitatively surveyed the daily clinical outcome of mice by using a cumulative clinical score (maximum 12 points), addressing the abundance of blood in feces (0: no blood; 2: microscopic detection of blood by the Guajac method using Haemoccult, Beckman Coulter/PCD, Krefeld, Germany; 4: macroscopic blood visible), the stool consistency (0: formed feces; 2: pasty feces; 4: liquid feces) and the clinical aspect (i.e., wasting symptoms; 0: normal; 1: ruffled fur; 2: less locomotion; 3: isolation; 4: severely compromised locomotion, pre-final aspect) as described earlier [47 (link)].
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Quantitative Clinical Scoring in Mice
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Corresponding Organization : Freie Universität Berlin
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Variable analysis
independent variables
- Infection
- Abundance of blood in feces
- Stool consistency
- Clinical aspect (i.e., wasting symptoms)
- None explicitly mentioned
- None explicitly mentioned
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