At recruitment, maternal age, ethnicity, highest educational attainment, household income, and self-reported pre-pregnancy weight were collected through interviewer-administered questionnaires. At the 26-28 week antenatal visit, maternal height (SECA213 Stadiometer, SECA Corp, Hamburg, Germany) and venous fasting plasma glucose [Advia 2400 Chemistry system (Siemens Medical Solutions Diagnostics, Deerfield, IL, USA) and Beckman LX20 Pro analyser (Beckman Coulter, USA)] were measured. Tobacco exposure was assessed through plasma cotinine and interviewer-administered questionnaires 23 (link). Total gestational weight gain was calculated from pre-pregnancy weight and last measured antenatal weight. Gestational age was calculated from the first trimester ultrasound scan. Infant sex and maternal hypertensive disorders (including chronic hypertension, pregnancy-induced hypertension, and pre-eclampsia) were obtained from medical records. In a subset of neonates (N=160) whose parents consented, neonatal abdominal adiposity, namely the subcutaneous adipose tissue, superficial subcutaneous adipose tissue, deep subcutaneous adipose tissue, and intraabdominal adipose tissue volumes were measured by magnetic resonance imaging using a GE Signa HDxt 1.5T magnetic resonance scanner (GE Healthcare) within 2 weeks from delivery.
Protocol detail
Maternal Factors and Neonatal Adiposity
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Cotinine
Delivery
Diagnostics
Ethnicity
Gestational age
Glucose
Household
Hypertension
Infant
Interviewer
Intraabdominal adipose tissue
Magnetic resonance
Maternal
Neonatal
Parents
Plasma
Pre eclampsia
Pregnancy
Pregnancy induced hypertension
Subcutaneous adipose tissue
Tobacco
Ultrasound scan
Venous
Corresponding Organization :
Other organizations : National University of Singapore, Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, Harvard Pilgrim Health Care, Harvard University, National Taiwan University, KK Women's and Children's Hospital, National University Heart Centre Singapore, Khoo Teck Puat Hospital, Duke-NUS Medical School, University of Auckland, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, MRC Lifecourse Epidemiology Unit, National University Health System, University of Helsinki, Folkhälsans Forskningscentrum, Medical Research Council, University of Cambridge, MRC Epidemiology Unit
Top 5 similar protocols
Variable analysis
independent variables
- Maternal age
- Ethnicity
- Highest educational attainment
- Household income
- Self-reported pre-pregnancy weight
- Maternal height
- Venous fasting plasma glucose
- Tobacco exposure (plasma cotinine and interviewer-administered questionnaires)
- Total gestational weight gain
- Gestational age
- Infant sex
- Maternal hypertensive disorders (including chronic hypertension, pregnancy-induced hypertension, and pre-eclampsia)
- Neonatal abdominal adiposity (subcutaneous adipose tissue, superficial subcutaneous adipose tissue, deep subcutaneous adipose tissue, and intraabdominal adipose tissue volumes)
- SECA213 Stadiometer (for measuring maternal height)
- Advia 2400 Chemistry system (Siemens Medical Solutions Diagnostics, Deerfield, IL, USA) and Beckman LX20 Pro analyser (Beckman Coulter, USA) (for measuring venous fasting plasma glucose)
- GE Signa HDxt 1.5T magnetic resonance scanner (GE Healthcare) (for measuring neonatal abdominal adiposity)
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