Progesterone-Boronic Acid Cocrystal Formation

Example 2

157.3 mg of progesterone and 75.2 mg of 4-formylbenzeneboronic acid were weighed and mixed, 3 ml of a methanol-ethanol-water (volume ratio=1:1:1) mixed solvent was added and stirred at 70° C. for 30 min until a completely clear solution was obtained, then the solution was allowed to stand at room temperature for 4 days to volatilize the solvent and precipitate crystals, and a cocrystal of progesterone was obtained after filtering and drying. The obtained cocrystal was subjected to single-crystal X-ray diffraction analysis. Its crystal data and structural parameters are shown in Table 1, indicating that the obtained crystal is a progesterone-4-formylbenzeneboronic acid cocrystal.