Example 5
Additional formulations which vary the amounts of transcutol and ethyl alcohol were examined by the same procedure.
Formulations tested (Table 4):
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Protocol detail
Formulation Optimization for Transdermal Diclofenac
Acid
Alcohol
Cyclooxygenase inhibitors
Delivery
Diclofenac
Diclofenac sodium
Dmso
Figs
Head
Hydroxypropyl cellulose
Oleic acid
Poloxamer
Propylene glycol
Skin
Sodium
Transcutol
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Variable analysis
independent variables
- Amounts of transcutol and ethyl alcohol
- Transdermal dose
- Dose retained in the skin
- Percent delivery of diclofenac
- Positive control: Pennsaid (2% Diclofenac solution)
- Negative control: Not mentioned
Annotations
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