Seventy-two rats were classified into four groups of 18 rats each, where group I was control and animals in group II, group III and group IV were treated with drug suspension, transethosomes and optimal PB, respectively. A known volume (0.5 mL) of drug suspension, transethosomes and optimal PB was added non-occlusively to dorsal rat’s skin on a specific area that was shaved earlier. After various time intervals of treatment (1, 2, 4, 6, 8 and 10 hrs), three rats per group were killed and the dorsal rat’s skin was cut and analyzed.3 (link),7 (link),11 (link) AUC0–10 values were calculated and compared between treatments. Statistical significance was studied using one-way ANOVA adopting SPSS® software 22.0. Post-hoc test was conducted using Tukey’s HSD test.
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Transdermal Drug Delivery: Comparative Analysis
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Corresponding Organization :
Other organizations : Misr University for Science and Technology, Cairo University, October 6 University
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Variable analysis
independent variables
- Drug suspension
- Transethosomes
- Optimal PB
- AUC0–10 values
- Dorsal rat's skin
- Volume of drug suspension, transethosomes, and optimal PB (0.5 mL)
- Time intervals of treatment (1, 2, 4, 6, 8, and 10 hrs)
- Group I (control group)
- Not mentioned
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