Cardiac MRI Analysis of Single Ventricle

All study images were reviewed and interpreted by a single investigator with expertise in congenital CMR imaging. Institutional post-processing software (Qmass MR and Qflow, Medis) was utilized for off-line image analysis. Contouring of the single ventricle at end-systole and end-diastole was performed to quantify ventricular volumes and calculation of ejection fraction as a measure of global systolic function. Additional off-line processing of horizontal longaxis tissue strain and strain rate was performed using CVI 42 Tissue Tracking software (Circle Cardiovascular Imaging, Calgary, Canada) for further characterization of myocardial mechanics [24 (link), 25 (link)].

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Rubinstein J., Woo J.G., Garcia A.M., Alsaied T., Li J., Lunde P.K., Moore R., Laasmaa M., Sammons A., Mays W.A., Miyamoto S.D., Louch W.E, & Veldtman G. (2020). Probenecid improves cardiac function in subjects with a Fontan circulation and augments cardiomyocyte calcium homeostasis. Pediatric cardiology, 41(8), 1675-1688.

Publication 2020

CVI 42 Tissue Tracking software

Cardiovascular Diastole Mechanics Myocardial Single ventricle Strain Systolic Tissue Ventricular

Corresponding Organization : University of Cincinnati Medical Center

Other organizations : University of Colorado Denver, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, University of Oslo, Institutt for Eksperimentell Medisinsk Forskning, Oslo University Hospital, Cincinnati Children's Hospital Medical Center, King Faisal Specialist Hospital & Research Centre

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Ventricular volumes
Ejection fraction
Horizontal long-axis tissue strain
Strain rate

control variables

Single investigator with expertise in congenital CMR imaging
Institutional post-processing software (Qmass MR and Qflow, Medis) for off-line image analysis
Contouring of the single ventricle at end-systole and end-diastole

controls

None explicitly mentioned

Annotations

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