Progesterone-3-Nitrophthalic Acid Cocrystal Synthesis

Example 3

157.2 mg of progesterone and 105.0 mg of 3-nitrophthalic acid were weighed and mixed, 3 ml of an ethanol-water (volume ratio=1:1) mixed solvent was added and stirred at 75° C. for 45 min until a completely clear solution was obtained, then the solution was allowed to stand at room temperature for 5 days to volatilize the solvent and precipitate crystals, and a cocrystal of progesterone was obtained after filtering and drying. The obtained cocrystal was subjected to single-crystal X-ray diffraction analysis. Its crystal data and structural parameters are shown in Table 1, indicating that the obtained crystal is a progesterone-3-nitrophthalic acid cocrystal.