Specifically, left ventricle (LV) endocardial and epicardial borders and the right ventricle (RV) endocardial borders were manually traced in SAX slices at end-diastole (ED) and end-systole (ES) time frames using the cvi42 post-processing software (version 5.1.1, Circle Cardiovascular Imaging Inc., Calgary, Alberta, Canada). ED and ES phases were defined, respectively, as the image with the largest and smallest LV blood volume at visual inspection. The manual contours and the corresponding images were saved for later processing.
Cardiac MRI Manual Segmentation Protocol
Specifically, left ventricle (LV) endocardial and epicardial borders and the right ventricle (RV) endocardial borders were manually traced in SAX slices at end-diastole (ED) and end-systole (ES) time frames using the cvi42 post-processing software (version 5.1.1, Circle Cardiovascular Imaging Inc., Calgary, Alberta, Canada). ED and ES phases were defined, respectively, as the image with the largest and smallest LV blood volume at visual inspection. The manual contours and the corresponding images were saved for later processing.
Corresponding Organization : The Alan Turing Institute
Other organizations : Circle Cardiovascular Imaging, National Heart Centre Singapore, National University of Singapore, Asia University, University College London, Newham University Hospital
Variable analysis
- Manual segmentation performed by a group of experienced investigators from the National Heart Centre Singapore (NHCS), consisting of CMR consultants, well-trained clinical research fellows and engineers
- Left ventricle (LV) endocardial and epicardial borders
- Right ventricle (RV) endocardial borders
- Standardized protocol described in a separate publication (14 (link))
- Two operators with over five years' experience (LTT and CWLC) checked the contouring quality to select the studies deemed for further analysis
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