Diagnostic Criteria and Treatment for Primary Aldosteronism

The diagnosis of PA was confirmed if patients met the following three criteria: (1) aldosterone-to-renin ratio > 35, (2) a TAIPAI score > 60%, and (3) post-saline loading PAC > 10 ng/dl or aldosterone-to-renin ratio > 35 (ng/dl)/(ng/ml/h) in the post-captopril test; or PAC > 6 ng/dl in the fludrocortisone suppression test. Details of the protocol can be found in our previous study.^{12 (link)}The treatment of PA was either pharmaceutical with mineralocorticoid receptor antagonists or surgical resection with laparoscopic adrenalectomy via a lateral transperitoneal approach performed by experienced operators.

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Kao T.W., Wu X.M., Liao C.W., Tsai C.H., Chen Z.W., Chang Y.Y., Lee B.C., Chiu Y.W., Lai T.S., Wu V.C., Lin Y.H, & Hung C.S. (2023). Anatomical and functional remodeling of left ventricle in patients with primary aldosteronism and concomitant albuminuria. Therapeutic Advances in Chronic Disease, 14, 20406223221143253.

Publication 2023

Adrenalectomy Aldosterone Captopril Diagnosis Fludrocortisone Laparoscopic surgical Mineralocorticoid receptor antagonists Patients Pharmaceutical Renin Saline

Corresponding Organization :

Other organizations : National Taiwan University Hospital, Tao Yuan General Hospital, National Taiwan University, Far Eastern Memorial Hospital, Yuan Ze University

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Variable analysis

independent variables

Treatment of PA: pharmaceutical with mineralocorticoid receptor antagonists or surgical resection with laparoscopic adrenalectomy via a lateral transperitoneal approach

dependent variables

Aldosterone-to-renin ratio > 35
TAIPAI score > 60%
Post-saline loading PAC > 10 ng/dl or aldosterone-to-renin ratio > 35 (ng/dl)/(ng/ml/h) in the post-captopril test
PAC > 6 ng/dl in the fludrocortisone suppression test

control variables

Performed by experienced operators

Annotations

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