Cisplatin (TEVA Pharmaceuticals, North Wales, PA) was diluted in sterile PBS and administered i.p. at a dose of 2.3 mg/kg per day for 5 days followed by 5 days of rest and another 5 days of injections[46 (link)]. The HDAC6 inhibitor ACY-1215 (Regenacy Pharmaceuticals) was prepared in 10% DMSO, 30% Propylene glycol and 60% Poly(ethylene glycol)-300, and was administered daily via oral gavage at 30 mg/kg 1 hour prior to each Cisplatin injection[32 (link)].
Protocol detail
Cisplatin and HDAC6 inhibitor regimen
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Cisplatin
Dmso
Gavage
Hdac6 inhibitor acy 1215
Pharmaceuticals
Poly ethylene glycol 300
Propylene glycol
Sterile
Corresponding Organization : The University of Texas MD Anderson Cancer Center
Other organizations : Friedrich Miescher Institute
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Variable analysis
independent variables
- Cisplatin (TEVA Pharmaceuticals, North Wales, PA)
- HDAC6 inhibitor ACY-1215 (Regenacy Pharmaceuticals)
- Not explicitly mentioned
- Sterile PBS (used to dilute Cisplatin)
- 10% DMSO, 30% Propylene glycol and 60% Poly(ethylene glycol)-300 (used to prepare ACY-1215)
- Positive control: Not mentioned
- Negative control: Not mentioned
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