Studies were performed on a 3.0T scanner (GE Healthcare, Milwaukee, WI, USA) using a single-shot, flow-compensated, spin-echo EPI pulse sequence. Shear waves were introduced into the brain from an active driver engine located outside of the scan room through a soft pillow-like passive driver placed under the subject's head within an 8-channel receive-only head coil [20 (link)]. The frequency of vibration was 60 Hz and the MRE sequence was performed using the following parameters: TR/TE=3600/62 ms; field of view (FOV)=24 cm; BW=±250 kHz; 72×72 imaging matrix reconstructed to 80×80; 3x parallel imaging acceleration, frequency encoding in the anterior-posterior direction; 48 contiguous 3-mm-thick axial slices; one 4-G/cm 18.2-ms zeroth- and first-order moment nulled motion-encoding gradient on each side of the refocusing RF pulse synchronized to the motion; motion encoding in the positive and negative x, y and z directions; and 8 phase offsets sampled over one period of the 60 Hz motion (the acquisition time was under 7 minutes). The acquired images had 3-mm isotropic resolution.