Synbiotic Supplement for Subclinical Hypothyroidism

The target population was adults with hypothyroidism. Inclusion criteria were: Women or men, 25–65 years old (protocol amendment), with subclinical hypothyroidism (elevated TSH level and a normal or low free T4 level) for at least 6 months (protocol amendment), and BMI less than 35 who were being treated by levothyroxine. Exclusion criteria were: Lactating or pregnancy; History of taking probiotic or synbiotic supplements in the last three months; Smoking or alcohol consumption; Taking appetite suppressants such as antibiotics; Use of antibiotics and any medications that interact with synbiotics; Gastrointestinal diseases such as stomach ulcers, diarrhea or constipation etc. for three months before or during the intervention; Unwillingness to continue cooperation, and non-compliance during the intervention. Participants were also excluded in case of catching infectious diseases such as Covid-19, occurrence of pregnancy, and undergoing surgery during the study period.

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Ramezani M., Reisian M, & Sajadi Hezaveh Z. (2023). The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial. PLOS ONE, 18(2), e0277213.

Publication 2023

Adults Antibiotics Appetite suppressants Constipation Covid 19 Diarrhea Gastrointestinal diseases Infectious diseases Levothyroxine Low t4 Medications Pregnancy Probiotic Stomach ulcers Supplements Surgery Synbiotics Target population Women

Corresponding Organization : Iran University of Medical Sciences

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Variable analysis

independent variables

Synbiotic supplementation

dependent variables

TSH level
Free T4 level

control variables

Age (25-65 years)
Gender (Women or men)
Subclinical hypothyroidism (elevated TSH level and a normal or low free T4 level) for at least 6 months
BMI less than 35
Treatment with levothyroxine
No lactation or pregnancy
No history of taking probiotic or synbiotic supplements in the last three months
No smoking or alcohol consumption
No use of appetite suppressants such as antibiotics
No use of antibiotics and any medications that interact with synbiotics
No gastrointestinal diseases such as stomach ulcers, diarrhea or constipation for three months before or during the intervention
Willingness to continue cooperation and compliance during the intervention
No infectious diseases such as Covid-19, occurrence of pregnancy, and undergoing surgery during the study period

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