Biginelli-type Access to Androstano-Arylpyrimidine Derivatives

The Biginelli-type multicomponent access to androstano-arylpyrimidine 17-acetates (compounds labeled by number 10) and 17-OH derivatives (compounds labeled as 11) under microwave irradiation was published by our group in Baji et al. [24 (link)]. The original compound numbers used in Baji et al. were retained in the present manuscript for clarity and comparability.
The chemotherapy drugs Bleomycin, Carmustine, Cisplatin, Doxorubicin, and Epirubicin were obtained from the Central Pharmacy of the University of Szeged (Szeged, Hungary).

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Nagy F.I., Adamecz D.I., Baji Á., Kiricsi Á., Huliák I., Rónavári A., Kónya Z., Frank É., Gopisetty M.K, & Kiricsi M. (2023). Semi-Synthetic Dihydrotestosterone Derivatives Modulate Inherent Multidrug Resistance and Sensitize Colon Cancer Cells to Chemotherapy. Pharmaceutics, 15(2), 584.

Publication 2023

Acetates Bleomycin Carmustine Chemotherapy Cisplatin Derivatives Doxorubicin Drugs Epirubicin Microwave irradiation

Corresponding Organization : Heidelberg University

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Variable analysis

independent variables

Microwave irradiation

dependent variables

Synthesis of androstano-arylpyrimidine 17-acetates (compounds labeled by number 10)
Synthesis of 17-OH derivatives (compounds labeled as 11)

control variables

Chemotherapy drugs: Bleomycin, Carmustine, Cisplatin, Doxorubicin, and Epirubicin

positive controls

Not specified

negative controls

Not specified

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