Femoral Microarchitecture Analysis via Micro-CT

To evaluate skeletal microarchitecture, the right femora (n = 6) were subjected to a high-resolution Micro-CT analysis using a Micro-CT imaging system (Siemens, Inveon), according to the method described in a publication [41 (link)].
The quantitative parameters of the bone microstructure were measured, including BV/TV, BS/BV, Tb.Th, Tb.N, Tb.Sp and BMD. All the digitalized data and 3-dimensional images were supplied by the built-in software of Micro-CT (Siemens, Inveon).

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Sun X., Wei J., Lyu J., Bian T., Liu Z., Huang J., Pi F., Li C, & Zhong Z. (2019). Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis. Journal of Nanobiotechnology, 17, 10.

Publication 2019

Micro-CT Micro-CT imaging system

Bone Femora Micro ct Skeletal

Corresponding Organization : Southwest Medical University

Other organizations : Affiliated Hospital of Southwest Medical University, First Affiliated Hospital of Sichuan Medical University

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Variable analysis

independent variables

Right femora (n = 6)

dependent variables

BV/TV (Bone Volume/Total Volume)
BS/BV (Bone Surface/Bone Volume)
Tb.Th (Trabecular Thickness)
Tb.N (Trabecular Number)
Tb.Sp (Trabecular Separation)
BMD (Bone Mineral Density)

control variables

Micro-CT imaging system (Siemens, Inveon)
Built-in software of Micro-CT (Siemens, Inveon)

controls

No positive or negative controls were explicitly mentioned in the information provided.

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