Fever Diagnosis Biomarker Protocol

All test samples (including PCT and blood culture) were collected within the first 12 h after the development of fever in patients. The “criterion of fever” was a body temperature ≥ 38.0°C [9 (link)]. Blood samples were cultured using an American BD FX400 automatic blood culture system (Becton, Dickinson and Company, USA). Blood culture results were defined as negative (no infection) if there was no microbial growth after five days. The PCT levels were measured using a Roche E411 autoimmune analyzer (Roche Diagnostics, Germany), and D-dimer levels were analyzed using an ACL TOP700 analyzer (Werfen Inc., Spain); the serum biochemical indices were measured using an AU5832 automatic biochemical analyzer (Beckman Coulter Inc.). The blood routine index was analyzed using an XN-20 analyzer (SYSMEX, Japan).

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Li S.S., Gu J.X., Li X.W., Zhang N., Jia M., Pei L, & Su M. (2022). Association of Procalcitonin with the Patient's Infection Characteristics and Prognosis after Hematopoietic Stem Cell Transplantation. Disease Markers, 2022, 9157396.

Publication 2022

XN-20 analyzer

Blood Blood culture Blood system Body temperature D dimer Diagnostics Fever Infection Patients Serum

Corresponding Organization : Peking University

Other organizations : Capital Medical University, China Rehabilitation Research Center

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Variable analysis

independent variables

Time of sample collection (within first 12 h of fever development)

dependent variables

Microbial growth in blood culture
Procalcitonin (PCT) levels
D-dimer levels
Serum biochemical indices
Blood routine index

control variables

Fever criterion (body temperature ≥ 38.0°C)

controls

Negative control: No microbial growth in blood culture after five days (defined as no infection)

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