Magnetoencephalography Protocol for Brain Connectivity

Magnetoencephalography (MEG) measurements were recorded using a 306-channel, whole-head MEG system (ElektaNeuromag Oy, Helsinki, Finland) in a magnetically shielded room (Vacuumschmelze GmbH, Hanau, Germany). Participants were instructed to lie on a bed with their eyes closed but to stay awake and reduce eye movements in order to minimize artifacts. Participants were scanned for 5 min with eyes closed, 2 min with eyes open, and another 5 min with eyes closed. On MEG we used source-reconstructed time series (10.1016/j.neuroimage.2011.11.005) to extract both frequency spectrum properties (relative band power and peak frequency) and functional connectivity between regions, as well as network topology using modern network theory (synchronization likelihood, modularity, path length, phase lag index) [79 (link), 80 (link)]. These analysis techniques were applied using BrainWave software (http://home.kpn.nl/stam7883/brainwave.html) [81 (link)] and inhouse MATLAB scripts (MATLAB Release 2012a; The MathWorks, Inc., Natick, MA, USA).

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Konijnenberg E., Carter S.F., ten Kate M., den Braber A., Tomassen J., Amadi C., Wesselman L., Nguyen H.T., van de Kreeke J.A., Yaqub M., Demuru M., Mulder S.D., Hillebrand A., Bouwman F.H., Teunissen C.E., Serné E.H., Moll A.C., Verbraak F.D., Hinz R., Pendleton N., Lammertsma A.A., van Berckel B.N., Barkhof F., Boomsma D.I., Scheltens P., Herholz K, & Visser P.J. (2018). The EMIF-AD PreclinAD study: study design and baseline cohort overview. Alzheimer's Research & Therapy, 10, 75.

Publication 2018

306-channel, whole-head MEG system MATLAB Release 2012a

Brainwave Eye movements Eyes Head

Corresponding Organization :

Other organizations : Amsterdam Neuroscience, University of Manchester, Maastricht University

Top 5 similar protocols

Variable analysis

independent variables

Eyes closed
Eyes open

dependent variables

Frequency spectrum properties (relative band power and peak frequency)
Functional connectivity between regions
Network topology (synchronization likelihood, modularity, path length, phase lag index)

control variables

Participants were instructed to lie on a bed with their eyes closed but to stay awake and reduce eye movements in order to minimize artifacts.

controls

No positive or negative controls were explicitly mentioned.

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