Progesterone Cocrystals' Water Sorption

Example 8

The progesterone monomer and the cocrystals of progesterone obtained in Examples 1-6 were subjected to dynamic vapour sorption analysis. The nitrogen flow rate was 200 ml/min, and the relative humidity, varied in a stepped manner by a change of 10%, increased from 20% to 80%, and then dropped to 0%. The water sorption kinetic curves at 25° C. were determined, and the results are shown in FIGS. 4, 1-4, 2-4 and 3-4. During the whole process, the change in relative mass of progesterone is less than 0.2%, indicating that progesterone is non-hygroscopic, and will neither absorb water nor be dehydrated when exposed to an environment with a certain humidity level. The changes in relative mass of the cocrystals of progesterone were also less than 0.2%, indicating that the obtained cocrystals of progesterone maintain the non-hygroscopic property of progesterone, and meet the basic requirements for a medicine.