Trehalose Therapy in Myocardial Infarction

The rats were divided into three groups (n = 8): (1) Sham group; (2) Myocardial Infarction (MI) group, which was subjected to MI surgery by permanent left anterior descending coronary artery (LAD) ligation technique; and (3) Trehalose-treated group (MI + TRE), which was subjected to MI surgery at day 0 followed by drinking a 2% solution of trehalose (Trehalose dihydrate, FUJIFILM Wako Pure Chemical Corporation, Japan) in the drinking water (7 (link), 22 (link)). All rats were kept under suitable environmental conditions and housed for four weeks.

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Farag A., Mandour A.S., Kaneda M., Elfadadny A., Elhaieg A., Shimada K, & Tanaka R. (2023). Effect of trehalose on heart functions in rats model after myocardial infarction: assessment of novel intraventricular pressure and heart rate variability. Frontiers in Cardiovascular Medicine, 10, 1182628.

Publication 2023

Trehalose dihydrate

Coronary artery Ligation Myocardial infarction Rats Surgery Trehalose

Corresponding Organization : Zagazig University

Other organizations : Suez Canal University, Damanhour University

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Variable analysis

independent variables

Group assignment: (1) Sham group, (2) Myocardial Infarction (MI) group, and (3) Trehalose-treated group (MI + TRE)

dependent variables

Outcomes measured after 4 weeks of treatment

control variables

Environmental conditions
Housing duration (4 weeks)

controls

Positive control: Sham group
Negative control: Myocardial Infarction (MI) group

Annotations

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