MRI scans were acquired on a 3.0 T scanner (GE Discovery MR750 W 3 T) using the same protocol for all participants, which included one T1- and three T2- weighted sequences. The 3D-T1w sequence was designed with an isotropic voxel size of 1 mm3 and a matrix size of 256x256x160 (TR/TE/TI = 8.0/3.7/450 ms, NSA = 1, flip angle = 8°). Three 3D-T2w sequences, with a voxel size of 1 mm × 1 mm × 3 mm, were also used: fluid attenuation inversion recovery (FLAIR: TR/TE/TI = 11,000/90/2600 ms, flip angle = 160°), fast spin echo (FSE: TR/TE = 5000/85 ms, flip angle = 110°) and, gradient echo (GRE: TR/TE = 1300/23 ms, flip angle = 15°).
All scans were visually assessed to verify their quality and to detect incidental findings by a trained neuroradiologist and have been reported elsewhere (Brugulat-Serrat et al. 2017 (link)). In this study, ten participants were excluded due to the presence of a meningioma, as well as 37 participants due to susceptibility, motion artefacts or segmentation problems, resulting in a total of 561 images available for subsequent analysis. The medial temporal lobe atrophy was assessed by Medial Temporal Atrophy scale (Scheltens et al. 1992 (link)).
All scans were visually assessed to verify their quality and to detect incidental findings by a trained neuroradiologist and have been reported elsewhere (Brugulat-Serrat et al. 2017 (link)). In this study, ten participants were excluded due to the presence of a meningioma, as well as 37 participants due to susceptibility, motion artefacts or segmentation problems, resulting in a total of 561 images available for subsequent analysis. The medial temporal lobe atrophy was assessed by Medial Temporal Atrophy scale (Scheltens et al. 1992 (link)).
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