Plasma Biomarkers for Neurological Diseases

Duplicate blood samples were analyzed in-house (Quanterix SRX analyzer), blinded to all clinical and demographic data, using single molecule array (Simoa) technology for p-tau181 (Quanterix Advantage v2 kit), GFAP, and NfL (Quanterix Neurology 2-Plex B). Our group previously reported separate plasma NfL data in a smaller sample of the 1FLADRC.^{19 (link)} NfL data are reported here in a larger cohort with different study aims and using a different Quanterix Simoa assay. Samples with coefficients of variation >20% were excluded (p-tau181: 10.8% of sample, GFAP: 7.4%, NfL: 6.3%). Additional sample collection and processing details are provided in Supplementary Methods.

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Asken B.M., Wang W., McFarland K., Arias F., Fiala J., Velez‐Uribe I., Mayrand R.P., Sawada L.O., Freytes C., Adeyosoye M., Marsiske M., Rosselli M., Barker W.W., Curiel Cid R., Loewenstein D.A., DeKosky S.T., Armstrong M.J., Smith G.E., Adjouadi M., Vaillancourt D.E, & Duara R. (2023). Plasma Alzheimer's biomarkers and brain amyloid in Hispanic and non‐Hispanic older adults. Alzheimer's & Dementia, 20(1), 437-446.

Publication 2023

SRX analyzer Advantage v2 kit Neurology 2-Plex B

Corresponding Organization : University of Florida Health

Other organizations : University of Florida, Florida Atlantic University, Florida International University, Mount Sinai Medical Center, University of Miami

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

P-tau181

control variables

Samples with coefficients of variation >20% were excluded (p-tau181: 10.8% of sample, GFAP: 7.4%, NfL: 6.3%)

controls

Not explicitly mentioned

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