Under an argon atmosphere, the benzonitrile derivative (1 mmol), amino alcohol (3 mL), and silica-supported propylsulfonic acid (0.1 g) were stirred for 4 h at 120°C. The reaction was cooled at room temperature and directly purified through silica-gel column chromatography to obtain the corresponding oxazole. The benzonitrile derivative, amino alcohol, chromatography eluent, yield (%), melting point (°C), recrystallization solvent, IR results, and 1H NMR results are reported for each of the compounds.
Protocol detail
Synthesis of Oxazole Derivatives
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1h nmr
Amino alcohol
Argon
Atmosphere
Benzonitrile
Chromatography
Gel chromatography
Oxazole
Propylsulfonic acid
Silica
Silica gel
Solvent
Corresponding Organization : Sapienza University of Rome
Other organizations : Istituto Superiore di Sanità, Centers for Disease Control and Prevention, University of Siena, Siena Biotech (Italy)
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Variable analysis
independent variables
- Benzonitrile derivative (1 mmol)
- Amino alcohol (3 mL)
- Silica-supported propylsulfonic acid (0.1 g)
- Yield (%)
- Melting point (°C)
- Reaction time (4 h)
- Reaction temperature (120°C)
- Reaction atmosphere (argon)
- The reaction was directly purified through silica-gel column chromatography to obtain the corresponding oxazole.
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