Tobacco Biomarker Exposure Assessment

This study examined 50 biomarkers associated with exposure to tobacco. Biomarkers were selected from several classes of known tobacco product constituents, including (1) nicotine metabolites, (2) TSNAs, (3) metals, (4) PAHs, and (5) VOCs. A complete listing of geometric means for all 50 biomarkers among each user group can be found in eTable 2 in the Supplement.
A representative biomarker from each panel was selected for visualization of study results based on its documented association with tobacco exposure and linkage to tobacco-related disease development or adverse health effects. These biomarkers included metabolites of nicotine, tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), lead, cadmium, naphthalene, pyrene, acrylonitrile, acrolein, and acrylamide.^{13 (link),31 (link),32 (link),33 (link),34 (link),35 (link),36 ,37 (link),38 (link),39 ,40 (link),41 ,42 (link)} To estimate nicotine exposure, total nicotine equivalents were calculated by taking the molar sum of cotinine and trans-3′-hydroxycotinine values. Table 1 outlines the potential clinical relevance of selected biomarkers.

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Goniewicz M.L., Smith D.M., Edwards K.C., Blount B.C., Caldwell K.L., Feng J., Wang L., Christensen C., Ambrose B., Borek N., van Bemmel D., Konkel K., Erives G., Stanton C.A., Lambert E., Kimmel H.L., Hatsukami D., Hecht S.S., Niaura R.S., Travers M., Lawrence C, & Hyland A.J. (2018). Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes. JAMA Network Open, 1(8), e185937.

Publication 2018

Acrolein Acrylamide Acrylonitrile Biomarkers Butanone Cadmium Cotinine Development disease Metals Molar Naphthalene Nicotine Nitrosamine Pahs Pyrene Supplement Tobacco Tobacco product Trans 3 hydroxycotinine

Corresponding Organization : Roswell Park Comprehensive Cancer Center

Other organizations : Centers for Disease Control and Prevention, Office of Science, National Institute on Drug Abuse, University of Minnesota, American Legacy Foundation

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Variable analysis

independent variables

Tobacco product constituents across several classes, including nicotine metabolites, TSNAs, metals, PAHs, and VOCs

dependent variables

50 biomarkers associated with exposure to tobacco
Geometric means of the 50 biomarkers among each user group
Representative biomarkers from each panel (metabolites of nicotine, NNK, lead, cadmium, naphthalene, pyrene, acrylonitrile, acrolein, and acrylamide)
Total nicotine equivalents (calculated from cotinine and trans-3'-hydroxycotinine values)

control variables

Not explicitly mentioned

controls

No positive or negative controls were explicitly mentioned in the input text.

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