Arginine-Stimulated Insulin Secretion Assay

AST was used to assess first-phase insulin secretion (FPIS) after overnight fasting for at least eight hours. After a baseline blood sample was collected, a 10% (wt/vol.) solution of arginine hydrochloride (5 g) (Shanghai Xinyi Jinzhu Pharmaceutical Co., Ltd., Shanghai, China) was injected intravenously within 30-45 s. Blood samples were obtained at 2, 4, and 6 min after injection (17 (link)). All anti-diabetic therapy was paused during the test.

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Huang H., Zheng X., Wen X., Zhong J., Zhou Y, & Xu L. (2023). Visceral fat correlates with insulin secretion and sensitivity independent of BMI and subcutaneous fat in Chinese with type 2 diabetes. Frontiers in Endocrinology, 14, 1144834.

Publication 2023

Arginine hydrochloride Blood Insulin secretion Pharmaceutical Therapy

Corresponding Organization :

Other organizations : Third Affiliated Hospital of Southern Medical University, Southern Medical University Shenzhen Hospital

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Variable analysis

independent variables

Intravenous injection of 10% (wt/vol.) solution of arginine hydrochloride (5 g)

dependent variables

First-phase insulin secretion (FPIS)

control variables

Overnight fasting for at least eight hours
Baseline blood sample before injection
Blood samples collected at 2, 4, and 6 minutes after injection

controls

No positive or negative controls were explicitly mentioned in the provided information.

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