Transgenic Mouse Models for Stat5 and Bcl6

Mice with deletion of the entire Stat5A/5B locus (Stat5^−/−) and mice with the entire Stat5A/5B locus gene flanked with loxP sites (Stat5^fl/fl) were used^{69 (link)}. The Stat5^fl/+ mice were bred with Stat5^+/− mice to generate Stat5^fl/− mice. CD8Cre transgenic mice, Ig^HEL (C57BL/6, MD4), sHEL (C57BL/6, ML5) transgenic mice, BM1 mice, Rag1-deficient mice, CD45.1 congenic mice, CXCR5-deficient mice, PD-1-deficient mice, Lag3-deficiect mice and CD40-deficient mice were obtained from the Jackson Laboratory. Bcl6^fl/flCD4Cre mice were also used^{70 (link)}. Mice were housed in the SPF animal facility at the Medical College of Wisconsin, the animal experiments were performed using protocols approved by the Institutional Animal Care and Use Committee.