These substrates can be synthesized from Mitsunobu Reaction with 2-Aryl-2,3-butadien-1-ol and TsNHBoc, then the Boc protecting group can be removed by TFA.1.
Synthesis of N-Fluorinated Sulfonamides
These substrates can be synthesized from Mitsunobu Reaction with 2-Aryl-2,3-butadien-1-ol and TsNHBoc, then the Boc protecting group can be removed by TFA.1.
Corresponding Organization : Zhejiang Normal University
Variable analysis
- 2-Phenyl-2, 3-butadien-1-ol (1.46g, 10 mmol)
- TsNHBoc (3.53g, 13 mmol)
- PPh3 (3.41g 13 mmol)
- DEAD (2.61g, 15 mmol)
- Sodium hydride (10 mmol, 2 equiv.)
- Sulfonamide (1 equiv.)
- NFSI (3 eq.)
- Allenyl imide product
- Fluorosulfonamide (N-F) product (25%-50% yield)
- Reaction temperature: 0°C, room temperature
- Reaction time: overnight
- Solvents: THF, DCM
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