Osteoporosis Fracture Transcriptome Analysis

The mRNA expression profile microarray data were obtained from the GEO dataset: GSE7158 series included 12 OP (low bone density) samples and 14 NC (high bone density) samples; GSE56814 series included 31 pre-treatment samples (15 OP and 16 NC) and 43 prognostic samples, and GSE56815 series included 40 pre-treatment samples (20 OP and 20 NC) and 40 post-treatment samples. For GSE56814 and GSE56815, sample data before treatment were used for difference analysis. As this study involves only a bioinformatics analysis of the GEO data set, no ethical approval was required. The inclusion criteria included age >18 years, osteoporosis fractures grades 1–4 according to OF classification, pathological fractures: osteoporotic fractures, fracture of at least 1 vertebral body, fractures of thoracic or lumbar vertebral body. The exclusion criteria included pathological neoplastic fractures, osteoporosis fractures (OF) grade 5 according to OF classification and AO type B and C fractures.

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Deng Y., Wang Y., Shi Q, & Jiang Y. (2023). Identification of hub genes associated with osteoporosis development by comprehensive bioinformatics analysis. Frontiers in Genetics, 14, 1028681.

Publication 2023

Body Bone density Fractures Low bone density Lumbar Lumbar vertebral Microarray Mrna Neoplastic Osteoporosis fractures Pathological fractures Sample treatment Vertebral body Vertebral fracture

Corresponding Organization : Nanchang University

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Variable analysis

independent variables

Osteoporosis (OP) vs. Normal Control (NC) samples

dependent variables

MRNA expression profile

control variables

Age > 18 years
Osteoporosis fractures grades 1-4 according to OF classification
Pathological fractures: osteoporotic fractures
Fracture of at least 1 vertebral body
Fractures of thoracic or lumbar vertebral body

controls

Positive controls not explicitly mentioned
Negative controls not explicitly mentioned

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