MR imaging was performed on 1.5T (Signa Explorer; GE Healthcare) and 3T (Discovery MR750; GE Healthcare) scanners using our institutional glioma-specific MR imaging protocol. While this protocol has undergone slight changes with time, the sequences relevant to this study have remained constant: 3D T1 fast-spoiled gradient recalled-echo brain volume (BRAVO), 3D T2 FLAIR, ASL, DSC, axial T2, and 3D T1 BRAVO postcontrast images.
ASL was performed using pseudocontinuous labeling with the following parameters: TR/TE/label time/postlabel delay ¼ 5500/ 2.5/1500/2000 ms, 3D background-suppressed fast-spin-echo stackof-spirals readout, and 4-mm in-plane and 6-mm through-plane resolution. ASL postprocessing was performed by an automated reconstruction script that sent CBF images to PACS.
Before acquisition of DSC perfusion images, a 0.05-mmol/kg dose of gadobenate dimeglumine was administered as a preload to help correct for leakage effects. 11 (link) DSC perfusion was performed with a 4-mL/s bolus of 0.05-mmol/kg gadobenate dimeglumine and single-echo gradient-echo-planar imaging using the following parameters: TR/TE ¼ 1800/35-40 ms, section thickness ¼ 5 mm, no interslice gaps with 20 slices covering the brain, flip angle ¼ 30°, matrix ¼ 128 Â 128 mm, FOV ¼ 240 mm.
ASL was performed using pseudocontinuous labeling with the following parameters: TR/TE/label time/postlabel delay ¼ 5500/ 2.5/1500/2000 ms, 3D background-suppressed fast-spin-echo stackof-spirals readout, and 4-mm in-plane and 6-mm through-plane resolution. ASL postprocessing was performed by an automated reconstruction script that sent CBF images to PACS.
Before acquisition of DSC perfusion images, a 0.05-mmol/kg dose of gadobenate dimeglumine was administered as a preload to help correct for leakage effects. 11 (link) DSC perfusion was performed with a 4-mL/s bolus of 0.05-mmol/kg gadobenate dimeglumine and single-echo gradient-echo-planar imaging using the following parameters: TR/TE ¼ 1800/35-40 ms, section thickness ¼ 5 mm, no interslice gaps with 20 slices covering the brain, flip angle ¼ 30°, matrix ¼ 128 Â 128 mm, FOV ¼ 240 mm.
