Cardiac MRI Imaging Protocol in MESA

At Exam 5 (2010–2012), MESA participants without contraindications underwent CMR using 1.5T scanners (Avanto and Espree, Siemens Medical Systems; Signa LX, GE Healthcare). The MESA CMR protocol has been described previously and was uniform across all study sites.^{18 (link)} Briefly, LV volumes, myocardial mass, and functional measures were assessed by a cine steady‐state free precession sequence. Twelve short axis slices, one 4‐chamber view and one 2‐ chamber view, were acquired as described previously. Additionally, 3 tagged short-axis slices (base, mid, apex) were additionally obtained. The protocol for tagged CMR has been previously described.^{19 (link)} Finally, a subset (n=1,342) of consenting participants with estimated glomerular filtration rates (eGFR) >60 mL/min/1.73m² (Northwestern study site) or >45 mL/min/1.73m² (remaining study sites) underwent late gadolinium enhanced (LGE) CMR 15 minutes after administration of 0.15 mmol/kg dose of gadolinium based contrast agent (Magnevist, Bayer Healthcare Pharmaceuticals, Montville, NJ). All MESA CMR images were analyzed for structure and function in a core laboratory and at a single image analysis center (Johns Hopkins Medical Center, Baltimore, MD).