Repeated Mild Traumatic Brain Injury

Bromodeoxyuridine (BrdU; 50 mg/kg/day) was injected on day 0–5 during the repeated injury paradigm^{39 (link)}. For AraC Infusions, Alzet Mini-Osmotic Pumps Model 1007D (DURECT Corporation, Cupertino, CA) were used to provide continuous systematic delivery of the vehicle saline control or 2% AraC (Sigma, St. Louis, MO, USA) after subcutaneous implantation^{40 (link)}. Infusions were performed 7 days prior to rmTBI and rSham at which time the pumps were removed on the day of surgery.

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Greer K., Basso E.K., Kelly C., Cash A., Kowalski E., Cerna S., Ocampo C.T., Wang X, & Theus M.H. (2020). Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments. Scientific Reports, 10, 15374.

Publication 2020

Alzet Mini-Osmotic Pumps Model 1007D

Arac Brdu Bromodeoxyuridine Day surgery Delivery Osmotic Repeated injury Saline

Corresponding Organization :

Other organizations : Virginia Tech

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Variable analysis

independent variables

Bromodeoxyuridine (BrdU) injection (50 mg/kg/day, on day 0-5 during the repeated injury paradigm)
AraC infusion (2% AraC or saline control) using Alzet Mini-Osmotic Pumps Model 1007D after subcutaneous implantation, performed 7 days prior to rmTBI and rSham

dependent variables

Not explicitly mentioned

control variables

Saline control for AraC infusion

controls

Positive control: 2% AraC infusion
Negative control: Saline infusion

Annotations

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