Solubility and Calorimetric Measurements of Phenacetin

All solubility determination and calorimetric measurements were carried out using analytical grade chemicals. Phenacetin (CAS: 62-44-2) was obtained from Sigma-Aldrich (Poznań, Poland). The solvents acetonitrile (CAS: 75-05-08), dimethylformamide (DMF, CAS: 68-12-2), dimethyl sulfoxide (DMSO, CAS: 67-68-5), and methanol (CAS: 67-56-1) were provided by Avantor (Gliwice, Poland), while 1,4-dioxane (CAS: 123-91-1) was purchased from Sigma-Aldrich. Sodium chloride, potassium chloride, and salicylic acid used for heat capacity measurements validation were obtained from Avantor (Gliwice, Poland). The zinc melting standard (99.999%) used for the DSC calibration and the indium wire (99.999%) for calibration and heat capacity measurement validation were provided by the DSC device manufacturer (PerkinElmer, Waltham, MA, USA).

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Przybyłek M., Kowalska A., Tymorek N., Dziaman T, & Cysewski P. (2021). Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents. Molecules, 26(13), 4078.

Publication 2021

Phenacetin acetonitrile dimethylformamide dimethyl sulfoxide methanol 1,4-dioxane Sodium chloride potassium chloride

Acetonitrile Calorimetric Device Dimethylformamide Dioxane Dmso Indium Methanol Phenacetin Potassium chloride Salicylic acid Sodium chloride Solvents Zinc

Corresponding Organization :

Other organizations : Nicolaus Copernicus University

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Variable analysis

independent variables

Solvent type (acetonitrile, dimethylformamide (DMF), dimethyl sulfoxide (DMSO), methanol, 1,4-dioxane)

dependent variables

Solubility of phenacetin
Calorimetric measurements

control variables

Use of analytical grade chemicals
Phenacetin (CAS: 62-44-2) obtained from Sigma-Aldrich (Poznań, Poland)
Solvents (acetonitrile, DMF, DMSO, methanol, 1,4-dioxane) provided by Avantor (Gliwice, Poland)
Sodium chloride, potassium chloride, and salicylic acid used for heat capacity measurements validation obtained from Avantor (Gliwice, Poland)
Zinc melting standard (99.999%) used for the DSC calibration and the indium wire (99.999%) for calibration and heat capacity measurement validation provided by the DSC device manufacturer (PerkinElmer, Waltham, MA, USA)

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