PET images were analyzed using coregistered MR images and a standardized template as previously described (2 (link)). Regional VT and rate constants from standard 1- and 2-tissue-compartment models (9 (link)) were calculated using PMOD, version 2.95 (PMOD Technologies Ltd.) (10 ), with the arterial input function corrected for radiometabolites. Because of the uptake of radioactivity in the skull with 18F-FMPEP-d2, 4 regions were drawn on the coregistered MR images of each subject and applied to the PET images: combined left and right parietal bones, 9.3 ± 0.8 cm3; occiput, 24.0 ± 1.5 cm3; and clivus, 5.2 ± 1.6 cm3.
To determine the minimal scanning time necessary to obtain stable values of VT, we analyzed the PET data from each subject after removing variable durations of the terminal portion of the scan. We analyzed brain data of all subjects from 0–300 to 0–30 min, with 10-min decrements.
To determine the minimal scanning time necessary to obtain stable values of VT, we analyzed the PET data from each subject after removing variable durations of the terminal portion of the scan. We analyzed brain data of all subjects from 0–300 to 0–30 min, with 10-min decrements.
