Alzheimer's Disease Comorbidities in China

Research approval was obtained from the People's Hospital of China Three Gorges University's Ethics Committee (approval No: PJ-KY2021-26). Patients were retrospectively screened from the China Three Gorges University affiliated People's Hospital from January 2015 to December 2020 and were collected from a hospital-based electronic database. We included subjects who were diagnosed with AD and had comorbidities on admission, a primary diagnosis on admission, and a main diagnoses based on the International Classification of Diseases (9^th edition), Clinical modification (ICD-9-CM; WHO 1999) codes (290.0–290.3, 294.1–294.2, and 331.0) and the International Classification of Diseases (10th edition) codes (G30.0–G30.1 and G30.8–G30.9). The enrolled patients had visited in the emergency department or outpatient department due to various clinical manifestations (including fever, cough, chest tightness, chest pain, palpitation, fatigue, edema, abdominal pain, diarrhea, loss of appetite, dizziness, headache, etc.) and were admitted to general wards by the outpatient department or emergency department. The inclusion criteria were as follows: (1) an AD discharge diagnosis and hospitalization for at least 24 h and (2) aged 60 years and over. The exclusion criteria were as follows: (1) basic information could not be obtained (2) vascular dementia, frontotemporal lobar degeneration, Lewy bodies dementia, Huntington's disease and mixed dementia (3) patients admitted to the intensive care unit, and (4) previous medical history information was missing. Demographic, patient comorbidities, and outcome information were collected from electronic medical records.