The contrast agent used in CEUS was SonoVue (Bracco SpA, Milan, Italy). The agents were microbubbles of the phospholipids microencapsulated sulfur hexafluoride (SF 6). The microbubbles had an average diameter of 2.5 μm and pH values of 4.5–7.5. After the SonoVue powder was thoroughly dissolved in 5 mL of normal saline, 2.4 mL of the solution was injected into the bolus through the cubital vein.
The ultrasound devices used included the Aplio500 (TOSHIBA CORPORATION, Tokyo, Japan), LOGIQ E9 GE (General Electric Company, Boston, Massachusetts, USA), EPIQ7 (Philips Electronic N.V, Amsterdam, The Netherlands), EUB-8500 (HITACHI, Tokyo, Japan), and Aixplorer (SuperSonic Imagine, Aix-en-Provence, France). The CEUS function was available on all of these devices. A linear array probe was used (frequency 5.0 -12.0 MHz).
The ultrasound devices used included the Aplio500 (TOSHIBA CORPORATION, Tokyo, Japan), LOGIQ E9 GE (General Electric Company, Boston, Massachusetts, USA), EPIQ7 (Philips Electronic N.V, Amsterdam, The Netherlands), EUB-8500 (HITACHI, Tokyo, Japan), and Aixplorer (SuperSonic Imagine, Aix-en-Provence, France). The CEUS function was available on all of these devices. A linear array probe was used (frequency 5.0 -12.0 MHz).
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