Additional validation was performed using a phantom study. A 6-mm-diameter 68 Ga-filled (2.1 MBq/ml) tube was submerged in water in a 20-cm-diameter cylindrical phantom and a 10-min PET acquisition was performed. Images were reconstructed using the same settings as the patient images. Masking and PVC were applied to the image slices where the tube was approximately parallel to the scanner axis (ca. 5 cm length) as described above, again using 38–46% thresholds and 2.0–2.4-mm kernel widths, and the bias of the resulting radioactivity concentrations relative to the known concentration was calculated for each threshold and kernel value.
Optimizing Carotid Artery Masking and PVC
Additional validation was performed using a phantom study. A 6-mm-diameter 68 Ga-filled (2.1 MBq/ml) tube was submerged in water in a 20-cm-diameter cylindrical phantom and a 10-min PET acquisition was performed. Images were reconstructed using the same settings as the patient images. Masking and PVC were applied to the image slices where the tube was approximately parallel to the scanner axis (ca. 5 cm length) as described above, again using 38–46% thresholds and 2.0–2.4-mm kernel widths, and the bias of the resulting radioactivity concentrations relative to the known concentration was calculated for each threshold and kernel value.
Corresponding Organization :
Other organizations : University of Gothenburg, Uppsala University, Umeå University
Variable analysis
- Threshold values (38-46%)
- Gaussian kernel widths (2.0-2.4 mm)
- Area under the curve (AUC) of IDIFs compared to BSIF
- Whole-brain grey matter CBF values
- Bias of radioactivity concentrations relative to the known concentration in the phantom study
- Theoretically expected optimal values for threshold and Gaussian kernel based on previous studies
- Reconstruction settings used for patient and phantom PET images
- Positive control: 6-mm-diameter 68Ga-filled tube submerged in water in a 20-cm-diameter cylindrical phantom
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