EXAMPLE 2

IngredientsAmount
Ticagrelor (mg)10
Gelatin (mg)40
Mannitol (mg)20
Methylparaben sodium (mg)10
Propylparaben sodium (mg)10
Zinc glycerate (mg)5
Aspartame (mg)2
Purified waterq.s. to 250 μl
    • 1) Dissolve Gelatin and other ingredients in purified water under stirring at 200-500 rpm.
    • 2) Make up the final volume of the solution using purified water.
    • 3) Mix the solution under stirring at 200 to 500 rpm for further 15 min.
    • 4) Dose the solution into each cavity of preformed blister sheets (preferably using dispensing pipette).
    • 5) Freeze the filled blisters at a temperature in the range of −20 to −110° C.
    • 6) Freeze dry the blisters in a lyophilizer.
    • 7) Place the blister sheet containing dried lyophilisates on the punched carrier web of the blister packaging machine to transport the blister sheets through the sealing station of the packaging machine
    • 8) Seal the blister with a lidding foil and punch into final blisters.

Free full text: Click here