Assessing Organ Function in Tumor-Bearing Mice

Whole blood was harvested from CT26 tumor-bearing mice treated with different drug regimens through retro-orbital bleeding. The serum was separated for blood biochemistry analysis through centrifugation at 3000 rpm for 15 min. Liver function was evaluated via the measurement of alanine aminotransferase (ALT) and aspartate transaminase (AST) levels. Heart function was evaluated via measuring plasma lactate dehydrogenase (LDH), lactate dehydrogenase isoenzyme 1 (LDH1), creatine kinase (CK), and creatinine kinase isoenzyme MB (CK-MB).

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Wang C., Xu J., Cheng X., Sun G., Li F., Nie G, & Zhang Y. (2024). Anti-lymphangiogenesis for boosting drug accumulation in tumors. Signal Transduction and Targeted Therapy, 9, 89.

Publication 2024

Corresponding Organization :

Other organizations : National Center for Nanoscience and Technology, University of Chinese Academy of Sciences

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Variable analysis

independent variables

Different drug regimens

dependent variables

Alanine aminotransferase (ALT) levels
Aspartate transaminase (AST) levels
Plasma lactate dehydrogenase (LDH) levels
Lactate dehydrogenase isoenzyme 1 (LDH1) levels
Creatine kinase (CK) levels
Creatinine kinase isoenzyme MB (CK-MB) levels

control variables

Whole blood harvested from CT26 tumor-bearing mice
Retro-orbital bleeding
Serum separation through centrifugation at 3000 rpm for 15 min

controls

No positive or negative controls were explicitly mentioned.

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