Retrospective Study of Laryngectomy

In this retrospective study, we included all patients who underwent TL between 2000 and 2020, at our institution, for a locally advanced (T3 or T4) squamous cell carcinoma of the larynx or hypopharynx, either as a primary therapeutic option or as a salvage procedure after failure of an LP program. The therapeutic strategy was elaborated for each specific patient during a multidisciplinary tumor board (MTB) discussion. The exclusion criteria were as follows: histology other than squamous cell carcinoma, tumor stage T1 or T2 at diagnosis, TL performed for an indication other than progressive cancer, salvage TL performed after a treatment other than a LP protocol (open or transoral partial laryngectomy, radiotherapy alone). LP protocols consisted of either cisplatin-based concurrent CRT or ICT (with PF before 2005 or TPF since 2005) followed by RT in good responders.