Compound I calcium salt EtOH solvate Form B was obtained via temperature cycling between 60° C. and 5° C. with cooling rate of 0.2° C./min of Compound I calcium salt hydrate Form A in EtOH: n-heptane (1:1, v:v).
A. X-Ray Powder Diffraction
Compound I calcium salt EtOH solvate Form B XRPD was performed with a Panalytical X'Pert3 Powder XRPD on a Si zero-background holder. The 2 theta position was calibrated against a Panalytical Si reference standard disc. The XRPD diffractogram for Compound I calcium salt EtOH solvate Form A is shown in FIG. 19 and summarized in Table 24.
US11873300B2. Crystalline forms of CFTR modulators (2024-01-16). Vertex Pharmaceuticals Incorporated [US]. Inventors: Yi Shi [US], Kevin J. Gagnon [US], Jicong Li [US], Jennifer Lu [US], Ales Medek [US], Muna Shrestha [US], Michael Waldo [US], Beili Zhang [US], Carl L. Zwicker [US], Corey Don Anderson [US], Jeremy J. Clemens [US], Thomas Cleveland [US], Timothy Richard Coon [US], Bryan Frieman [US], Peter Grootenhuis [US], Sara Sabina Hadida Ruah [US], Jason McCartney [US], Mark Thomas Miller [US], Prasuna Paraselli [US], Fabrice Pierre [US], Sara E. Swift [US], Jinglan Zhou [US].
Temperature cycling between 60°C and 5°C with cooling rate of 0.2°C/min
dependent variables
Obtaining Compound I calcium salt EtOH solvate Form B
control variables
Compound I calcium salt hydrate Form A in EtOH: n-heptane (1:1, v:v)
controls
Compound I calcium salt hydrate Form A in EtOH: n-heptane (1:1, v:v)
Annotations
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