Quantifying Tumor Glucose Metabolism with 18F-FDG PET/CT

In this assay of tumors, a maximum standardized uptake value (SUV_max) of a tumor was obtained for patients who underwent ¹⁸F-fluorodeoxyglucose (FDG) PET/computed tomography (CT). Biograph 6 Hi-Rez (Siemens Medical Systems, Washington, DC, USA) was used to carry out the assay. The measurement procedure of tumor SUV_max was described previously in detail.(6 (link),12 (link)) Patients fasted for at least 6 h before the ¹⁸F-FDG PET/CT analysis. One hour after the i.v. administration of 3.7 Mbq/kg ¹⁸F-FDG, a transmission scan using CT for attenuation correction and anatomical imaging was acquired for 90 s. The PET data were reconstructed using a combination of Fourier rebinning and the ordered-subset expectation maximization at iteration number 3 and subset 8 with attenuation correction based on CT data. An ROI was assigned to the primary lesion, including the highest uptake area (a circle of ROI, diameter 1 cm), and the SUV_max in ROI was calculated. The SUV was calculated according to the following formula: SUV = ROI activity (MBq/mL) / injected dose (MBq/kg of body weight).

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Nakamiya N., Ueda S., Shigekawa T., Takeuchi H., Sano H., Hirokawa E., Shimada H., Suzuki H., Oda M., Osaki A, & Saeki T. (2014). Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy. Cancer Science, 105(7), 833-839.

Publication 2014

Biograph 6 Hi-Rez

18f fluorodeoxyglucose Assay Body weight Computed tomography Patients Scan Transmission Tumor

Corresponding Organization :

Other organizations : Saitama Medical University, Hamamatsu Photonics (Japan)

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Maximum standardized uptake value (SUV_max) of tumor

control variables

PET/CT scanner used (Biograph 6 Hi-Rez, Siemens Medical Systems, Washington, DC, USA)
Fasting duration (at least 6 h before the ¹⁸F-FDG PET/CT analysis)
Time between ¹⁸F-FDG administration and PET/CT scan (1 h)
Injected dose of ¹⁸F-FDG (3.7 Mbq/kg)
PET data reconstruction method (Fourier rebinning and ordered-subset expectation maximization at iteration number 3 and subset 8 with attenuation correction based on CT data)
Region of interest (ROI) assignment (a circle of ROI, diameter 1 cm, including the highest uptake area)

controls

No positive or negative controls were explicitly mentioned in the protocol.

Annotations

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